Publications

A selection of published literature, describing the cutting-edge advances which MorphoSys’s technologies are based on.

2014  
"Characterization and screening of IgG binding to the neonatal Fc receptor"Neuber, T. et al.; MAbs. 2014 Jul 1;6(4). [Epub ahead of print]
2013  
"A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties"Tiller, T. et al.; MAbs. 2013 Apr 9;5(3). [Epub ahead of print]
"An automated immunoassay for early specificity profiling of antibodies"Frese, K. et al.; MAbs. 2013 Feb 14;5(2). [Epub ahead of print]
2012  
"Granulocyte macrophage-colony stimulating factor is a key mediator in experimental osteoarthritis pain and disease development"Cook, AD. et al,; Arthrithis research & therapy, Epub 2012 Sep 20
"Granulocyte-macrophage colony-stimulating factor is a key mediator in inflammatory and arthritic pain"Cook, AD. et al.; Annals of the rheumatic diseases, Epub 2012 Jul 24
"Phage Display"Petropoulos, K.; Methods in Molecoular Biology, Epub 2012 June
"Evaluation of combination therapies with MOR00208, an Fc-enhanced humanized CD19 antibody, in models of lymphoma"Winderlich, M. et al; Presentation given at the 2012 ASCO Annual Meeting, Jun 1-5; citation: Journal of Clinical Oncology 30: 2012 (suppl; abstr 6574)
2011  
"Gantenerumab: A Novel Human Anti-Aβ Antibody Demonstrates Sustained Cerebral Amyloid-β Binding and Elicits Cell-Mediated Removal of Human Amyloid-β"Bohrmann, B. et al; Journal of Alzheimer's Disease, Epub 2011 Sep 28
"Antibodies in Metabolic Diseases"Ahrens, B.; New Biotechnology, 2011 Sep, 28 (5)
"HuCAL PLATINUM, a Synthetic Fab Library Optimized for Sequence Diversity and Superior Performance in Mammalian Expression Systems"Prassler, J. et al; Journal of Molecular Biology, Epub 2011 Aug 12
"Synthetic Antibodies Designed on Natural Sequence Landscapes"Zhai, W. et al.; Journal of Molecular Biology, Epub 2011 Jul 23
"Effect of MOR202, a human CD38 antibody, in combination with lenalidomide and bortezomib, on bone lysis and tumor load in a physiologic model of myeloma"Endell, J. et al.; Presentation given at the 2011 ASCO Annual Meeting, Jun 3-7; citation: Journal of Clinical Oncology 29: 2011 (suppl; abstr 8078)
"Antibody Library Design Meets Drugability"Kunz, C. et al.; Presentation given at the Recombinant Antibodies Conference 2011, Barcelona, May 24
  • No abstract available
"Fully human antibodies against the Protease-Activated Receptor-2 (PAR-2) with anti-inflammatory activity"Giblin, P. et al.; Human Antibodies, 2011 Jan 1; 20(3): 83-94
2010  
"Structural basis of HIV-1 neutralization by affinity matured Fabs directed against the internal trimeric coiled-coil of gp41"Gustchina, E. et al.; PLoS Pathogens, 2010 Nov 11; 6(11): e1001182
"Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies"Ettenberg, S. et al.; PNAS Early Edition, 2010 Jul 21, Epub 2010 Jul 21
"Isolation and characterization of selective and potent human Fab inhibitors directed to the active site region of the two-component NS2B-NS3 proteinase of West Nile virus"Shiryaev, S. A. et al.; Biochemical Journal, 2010 Feb 16
2009  
"In vitro affinity maturation of HuCAL antibodies: complementarity determining region exchange and RapMAT technology"Prassler, J. et al.; Future Medicine, Immunotherapy, 2009 Jul, 1(4): 571-583
"Generation and screening of the synthetic Human Combinatorial Antibody Library HuCAL GOLD"Klagge, I.; Ed. Melvyn Little, Cambridge University Press, Recombinant Antibodies for Immunotherapy, 2009: 75-89
  • No abstract available 
"Development of recombinant human IgA for anticardiolipin antibodies assay standardization"Knappik, A. et al.; Annals of the New York Academy of Sciences, 2009 Sep, 1173:190-8
2008   
"In vitro affinity maturation of human GM-CSF antibodies by targeted CDR-diversification"Steidl, S. et al; Elsevier, Molecular Immunology, 2008 Nov, 46(1): 135-44. Epub 2008 Aug 21
"Fab MOR03268 triggers absorption shift of a diagnostic dye via packaging in a solvent-shielded fab dimer interface"Hillig, R.C. et al.; Elsevier, Journal of Molecular Biology, 2008 Mar 14, 377(1): 206-19. Epub 2008 Jan 5
"The Human Combinatorial Antibody Library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies"Rothe, C. et al.; Elsevier, Journal of Molecular Biology, 2008 Feb 29, 376(4): 1182-200. Epub 2007 Dec 15
2007  
"Selection of vimentin-specific antibodies from the HuCAL phage display library by substractive panning on formalin-fixed, paraffin-embedded tissue"Jarutat, T. et al.; Biological Chemistry, 2007 Jun, 388(6): 651-8
"Crystallization and molecular-replacement solution of a diagnostic fluorescent dye in complex with a specific Fab fragment"Hillig, R.C. et al.; Acta crystallographica. Section F, Structural Biology and Crystallization Communications, 2007 Mar 1, 63(Pt 3): 217-23. Epub 2007 Feb 23
"Recombinant monoclonal antibodies"Donzeau, M. et al; Methods in molecular biology, 2007, 378: 14-31
2006  
"Simultaneous metal chelate affinity purification and endotoxin clearance of recombinant antibody fragments"Zimmerman, T. et al.; Elsevier, Journal of Immunological Methods, 2006 Jul 31, 314(1-2): 67-73. Epub 2006 Jun 22
"Generation and optimization of human antagonistic antibodies against TIM-1 as potential therapeutic agents in fibrotic diseases"Brocks, B. et al.; Human Antibodies, 2006, 15(4): 115-24
"Isolation and comparative characterization of Ki-67 equivalent antibodies from the HuCAL phage display library"Jarutat, T. et al.; Biological Chemistry, 2006 Jul, 387(7): 995-1003
"Antibodies for proteomic research: Comparison of traditional immunization with recombinant antibody technology"Ohara, R. et al.; Proteomics, 2006 May, 6(9): 2638-46
2005  
"Efficacy of the fully human monoclonal antibody MOR102 (#5) against intercellular adhesion molecule 1 in the psoriasis-severe combined immunodeficient mouse model"  Boehncke, W.H. et al.; The British Journal of Dermatology, 2005 Nov, 153(4): 758-766. Epub 2005 Aug 11
"Protein microarrays for antibody profiling: Specificity and affinity determination on a chip"O. Poetz, et al.; Proteomics, 2005 Jun, 5(9): 2402-2411
"Characterization of high-affinity antibodies by electrochemiluminescence-based equilibrium titration"Haenel, C. et al.; Analytical Biochemistry, 2005 Apr 1, 339(1): 182-184
"Modern antibody technology: The impact on drug development"Moroney, S.E. et al.; Wiley-VCH Verlag, Modern Biopharmaceuticals - Vol. 3, 2005
ISBN: 3-527-31184-X
  • No abstract available
"Monoclonal antibodies from phage display libraries"Urban, M.; Arzneimittel-Forschung, 2005, 55 (11): 694-695
  • No abstract available
2004  
"Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats"Parsons, C.J. et al.; Hepatology, 2004 Nov, 40(5): 1106-15
"Generation, engineering and production of human antibodies using HuCAL"Ostendorp, R. et al.; Springer, Antibodies - Volume 2: Novel technologies and therapeutic use, 2004: 13-52; ISBN 0-306-48315-7 (v.2)
  • No abstract available
2003  
"Human combinatorial Fab library yielding specific and functional antibodies against the human fibroblast growth factor receptor 3"Rauchenberger, R. et al.; The Journal of Biological Chemistry, 2003 Oct 3, 278(40): 38194-38205
"Kirrel2, a novel immunoglobulin superfamily gene expressed primarily in beta cells of the pancreatic islets"Sun, C. et al.; Genomics, 2003 Aug, 82(2): 130-142
"From EST to IHC: human antibody pipeline for target research"Frisch, C. et al.; Journal of Immunological Methods, 2003 Apr 1, 275(1-2): 203-212
2002  
"Antibody discovery: Phage display"Kretzschmar, T. et al.; Current Opinion in Biotechnology, 2002 Dec, 13(6): 598-602
"Fully human, HLA-DR-specific monoclonal antibodies efficiently induce programmed death of malignant lymphoid cells"Nagy, Z. A. et al.; Nature Medicine, 2002 Aug, 8(8): 801-807
2001  
"High-throughput generation and engineering of recombinant human antibodies"Krebs, B. et al.; Journal of Immunological Methods, 2001 Aug 1, 254(1-2): 67-84
2000  
"Picomolar affinity antibodies from a fully synthetic naive library selected and evolved by ribosome display"Hanes, J. et al.; Nature Biotechnology, 2000 Dec, 18(12): 1287-1292
"Titration of infective and noninfective Ff filamentous bacteriophages using a monoclonal antibody against g3p"Frisch, C. et al.; BioTechniques, 2000 Jul, 29(1): 26-28
"Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides"Knappik, A. et al.; Journal of Molecular Biology, 2000 Feb 11, 296 (1): 57-86
"Bypassing hybridoma technology: HLA-C reactive human single-chain antibody fragments (scFv) derived from a synthetic phage display library (HuCAL) and their potential to discriminate HLA class I specificities"Marget,M. et al.; Tissue Antigens, 2000, 56: 1-9
1997  
"New protein engineering approaches to multivalent and bispecific antibody fragments"Plueckthun, A.; Immunotechnology, 1997 Jun, 3(2): 83-105
"Setting up a Biotechnology Business in Germany"Moroney, S.E.; Journal of Biotechnology in Healthcare, 1997 Apr 7, 4(1): 67-75.
  • No abstract available
1996  
"Multivalent antibody fragments with high functional affinity for a tumor-associated carbohydrate antigen"Rheinnecker, M. et al.; The Journal of Immunology, 1996 Oct 1, 157(7): 2989-2997
 1994  
"Trinucleotide phosphoramidites: ideal reagents for the synthesis of mixed oligonucleotides for random mutagenesis"Virnekaes, B. et al.; Nucleic Acids Research, 1994 Dec 25, 22(25): 5600-5607
 1993  
"Improved bivalent mini-antibodies, with identical avidity as whole antibodies, produced by high cell density fermentation of Eschericia coli"Pack, P. et al.; BIO/TECHNOLOGY, 1993 Nov, 11(11): 1271-1277