Clinical Pipeline

  • Proprietary Programs
  • Partnered Programs
  • Phase 1
  • Phase 2
  • Phase 3
  • Market
29 Antibodies available:
Program
Partner
Indication
Phase

Partner

Not partnered

Indication

Phase

Diffuse large B cell lymphoma (DLBCL) (B-MIND)
Phase 1 Phase 2 Phase 3 (Current Phase) Market
Chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) (COSMOS)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Diffuse large B cell lymphoma (DLBCL) (L-MIND)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
  • MOR208 (former XmAb®5574)
  • Target: CD19

Partner

I-Mab Biopharma*

Indication

Phase

Multiple myeloma (MM)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
  • A fully human HuCAL antibody
  • Target: CD38

* For development in Greater Chinese Market (China, Hong Kong, Taiwan, Macao).

Partner

Novartis/Galapagos

Indication

Phase

Atopic dermatitis (IGUANA) (iv)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Atopic dermatitis (bridging study) (sc)
Phase 1 (Current Phase) Phase 2 Phase 3 Market
  • A fully human Ylanthia antibody
  • Target: IL-17C

Partner

Not partnered

Indication

Phase

Undisclosed
Phase 1 (Current Phase) Phase 2 Phase 3 Market
  • Lanthipeptide
  • Target: AT2-R

Partner

Janssen/J&J

Indication

Phase

Plaque psoriasis
Phase 1 Phase 2 Phase 3 Market (Current Phase)
Psoriatic arthitis (PsA) & palmoplantar pustolosis (Japan only)
Phase 1 Phase 2 Phase 3 Market (Current Phase)
Plaque psoriasis (VOYAGE 1)
Phase 1 Phase 2 Phase 3 (Current Phase) Market
Plaque psoriasis (VOYAGE 2)
Phase 1 Phase 2 Phase 3 (Current Phase) Market
Pustular/Erythrodermic psoriasis
Phase 1 Phase 2 Phase 3 (Current Phase) Market
Plaque psoriasis
Phase 1 Phase 2 Phase 3 (Current Phase) Market
Plaque psoriasis (POLARIS)
Phase 1 Phase 2 Phase 3 (Current Phase) Market
Moderate to severe plaque psoriasis (SelfDose device)
Phase 1 Phase 2 Phase 3 (Current Phase) Market
Moderate to severe plaque psoriasis (ECLIPSE)
Phase 1 Phase 2 Phase 3 (Current Phase) Market
Psoriatic arthritis (PsA) (Discover-1)
Phase 1 Phase 2 Phase 3 (Current Phase) Market
Psoriatic arthritis (PsA)
Phase 1 Phase 2 Phase 3 (Current Phase) Market
Chronic plaque psoriasis (pediatric participants) (PROTOSTAR)
Phase 1 Phase 2 Phase 3 (Current Phase) Market
Crohn's disease (GALAXI 1)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Hidradenitis suppurativa (HS)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
  • A fully human HuCAL antibody
  • Target: IL23p19
  • Aliases: CNTO1959

Additional Information:

Gantenerumab

Partner

Roche

Indication

Phase

Early Alzheimer's disease (GRADUATE-1)
Phase 1 Phase 2 Phase 3 (Current Phase) Market
Early Alzheimer's disease (GRADUATE-2)
Phase 1 Phase 2 Phase 3 (Current Phase) Market
Mild Alzheimer's disease (Marguerite RoAD) (OLE)
Phase 1 Phase 2 Phase 3 (Current Phase) Market
Prodromal Alzheimer's disease (Scarlett RoAD) (OLE)
Phase 1 Phase 2 Phase 3 (Current Phase) Market
Genetically predisposed for Alzheimer's disease (DIAN)
Phase 1 Phase 2 Phase 3 (Current Phase) Market
  • A fully human HuCAL antibody
  • Target: Amyloid-beta

Additional Information:

Anetumab Ravtansine

Partner

Bayer AG

Indication

Phase

Mesothelioma
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Cancer, multi-indications
Phase 1 (Current Phase) Phase 2 Phase 3 Market
  • A fully human HuCAL-based antibody drug conjugate
  • Target: Mesothelin
  • Alias: BAY94-9343​

Additional Information:

BAY1093884

Partner

Bayer AG

Indication

Phase

Hemophilia A or B
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Hemophilia
Phase 1 (Current Phase) Phase 2 Phase 3 Market
  • A fully human HuCAL antibody
  • Target: tissue factor pathway inhibitor (TFPI)

Additional information:

BHQ880

Partner

Novartis

Indication

Phase

Multiple myeloma (MM) (renal insufficiency)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Smoldering multiple myeloma
Phase 1 Phase 2 (Current Phase) Phase 3 Market
  • A fully human HuCAL antibody
  • Target: DKK-1

Additional Information:

Bimagrumab

Partner

Novartis

Indication

Phase

Hip fracture surgery (efficacy, safety)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Sarcopenia (dose-ranging)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Sarcopenia (withdrawal extension study)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Type 2 diabetes
Phase 1 Phase 2 (Current Phase) Phase 3 Market
  • A fully human HuCAL antibody 
  • Target: ActRIIB
  • Aliases: BYM338

Additional information:

CNTO6785

Partner

Janssen/J&J

Indication

Phase

Chronic obstructive pulmonary disease (COPD)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Rheumatoid arthritis (RA)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
  • A fully human HuCAL antibody

Additional Information:

Ianalumab (VAY736)

Partner

Novartis

Indication

Phase

Pemphigus vulgaris
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Idiopathic pulmonary fibrosis
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Rheumatoid arthritis (RA)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
ADCC mediated B-Cell depletion & BAFF-R blockade (AMBER)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Primary Sjögren's syndrome (efficacy & safety)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Chronic lymphocytic leukemia (combo with ibrutinib)
Phase 1 (Current Phase) Phase 2 Phase 3 Market
  • A fully human HuCAL antibody 
  • Target: BAFF-R

Additional information:

NOV-12 (MAA868)

Partner

Novartis

Indication

Phase

Prevention of thrombosis
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Atrial fibrillation
Phase 1 Phase 2 (Current Phase) Phase 3 Market

Setrusumab (BPS804)

Partner

Novartis/Mereo

Indication

Phase

Brittle bone disease (Type I, III, IV) (ASTEROID)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
  • A fully human HuCAL antibody 
  • Target: Sclerostin

Additional information:

Tesidolumab (LFG316)

Partner

Novartis

Indication

Phase

Paroxysmal nocturnal hemoglobinuria
Phase 1 Phase 2 (Current Phase) Phase 3 Market
  • A fully human HuCAL antibody 
  • Target: C5

Additional Information:

Utomilumab (PF-05082566)

Partner

Pfizer

Indication

Phase

Breast cancer (AVIATOR)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Acute myeloid leukemia (AML)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Advanced Malignancies (combo with avelumab and PF-04518600) (Javelin Medley)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Solid tumors (combo with ISA101b vaccination)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Advanced malignancies (combo with avelumab & PF-04518600)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Solid tumors (combo with PF-04518600)
Phase 1 (Current Phase) Phase 2 Phase 3 Market
Colorectal cancer (combo with cetuximab & irinotecan)
Phase 1 (Current Phase) Phase 2 Phase 3 Market
Advanced ovarian cancer (T cell immunotherapy)
Phase 1 (Current Phase) Phase 2 Phase 3 Market
r/r DLBCL & MCL (avelumab plus utomilumab-based combination therapy)
Phase 1 (Current Phase) Phase 2 Phase 3 Market
Breast cancer (combo with trastuzumab emtansine or trastuzumab)
Phase 1 (Current Phase) Phase 2 Phase 3 Market
Diffuse large B cell lymphoma (Javelin DLBCL) (combo with avelumab)
Phase 1 (Current Phase) Phase 2 Phase 3 Market
  • A fully human HuCAL antibody
  • Target: 4-1BB (CD137)
  • Alias: PF-05082566

Additional Information:

Xentuzumab (BI-836845)

Partner

Boehringer Ingelheim

Indication

Phase

Breast cancer
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Castration-resistant prostate cancer (CRPC) (combo with enzalutamide)
Phase 1 Phase 2 (Current Phase) Phase 3 Market
Solid tumors (Japan)
Phase 1 (Current Phase) Phase 2 Phase 3 Market
Solid tumors (combo with abemaciclib)
Phase 1 (Current Phase) Phase 2 Phase 3 Market
EGFR mutant non-small cell lung cancer (NSCLC)
Phase 1 (Current Phase) Phase 2 Phase 3 Market
  • A fully human HuCAL antibody
  • Target: IGF-1

Additional Information:

Elgemtumab (LJM716)

Partner

Novartis

Indication

Phase

HER2+ cancer (combo with BYL719 & trastuzumab)
Phase 1 (Current Phase) Phase 2 Phase 3 Market
  • A fully human HuCAL antibody
  • Target: HER3

Additional information:

NOV-7 (CLG561)

Partner

Novartis

Indication

Phase

Eye disease
Phase 1 (Current Phase) Phase 2 Phase 3 Market

NOV-8

Partner

Novartis

Indication

Phase

Inflammation
Phase 1 (Current Phase) Phase 2 Phase 3 Market

NOV-9 (LKA651)

Partner

Novartis

Indication

Phase

Diabetic eye disease
Phase 1 (Current Phase) Phase 2 Phase 3 Market

NOV-10 (PCA062)

Partner

Novartis

Indication

Phase

Cancer
Phase 1 (Current Phase) Phase 2 Phase 3 Market

NOV-11

Partner

Novartis

Indication

Phase

Blood disorders
Phase 1 (Current Phase) Phase 2 Phase 3 Market

NOV-13 (HKT288)

Partner

Novartis

Indication

Phase

Cancer
Phase 1 (Current Phase) Phase 2 Phase 3 Market

NOV-14

Partner

Novartis

Indication

Phase

Asthma
Phase 1 (Current Phase) Phase 2 Phase 3 Market

PRV-300 (CNTO3157)

Partner

ProventionBio

Indication

Phase

Colitis (PULSE)
Phase 1 (Current Phase) Phase 2 Phase 3 Market
  • A fully human HuCAL antibody

Additional Information:

Vantictumab (OMP-18R5)

Partner

OncoMed

Indication

Phase

Breast cancer (combo with paclitaxel)
Phase 1 (Current Phase) Phase 2 Phase 3 Market
Pancreatic cancer (combo with nab-paclitaxel & gemcitabine)
Phase 1 (Current Phase) Phase 2 Phase 3 Market
  • A fully human HuCAL antibody
  • Target: Wnt signaling pathway (Fzd 7)
  • Alias: OMP-18R5

Additional information: