MorphoSys’s HuCAL® (Human Combinatorial Antibody Library) technology is a unique and innovative concept for the in vitro generation of highly specific and fully human antibodies.
The collection of several billion distinct, fully human antibodies allows for the rapid selection of antibodies with high affinity and specificity. The recombinant antibody technology of HuCAL® enables the generation of therapeutic and diagnostic antibodies, including those binding to difficult antigens.
HuCAL® antibodies are produced in bacteria, and the technology enables in vitro selection to isolate antibodies with the desired characteristics. HuCAL® is generated by de novo gene synthesis, and the large library is screened with a technique called phage display to identify the antibody with a high affinity to the investigated antigen.